USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P13639 USC-OGP 2-DE database:  P13639 P13639 General information about the entry View entry in simple text format Entry name EF2_HUMAN Primary accession number P13639 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Elongation factor 2; Short=EF-2;. Gene name Name=EEF2 Synonyms=EF2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1109: pI=6.53; Mw=110006 SPOT OGP-1203: pI=6.30; Mw=39011 Cross-references UniProtKB/Swiss-Prot P13639; EF2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name EF2_HUMAN Primary accession number P13639 Secondary accession number(s) B2RMP5 D6W618 Q58J86 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 191) Name and origin of the protein Description RecName: Full=Elongation factor 2; Short=EF-2; Gene name Name=EEF2 Synonyms=EF2 Encoded on Name=EEF2; Synonyms=EF2 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Elongation factor; GTP-binding; Isopeptide bond; Methylation; Neurodegeneration; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Spinocerebellar ataxia; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X51466; CAA35829.1; -; mRNA EMBL Z11692; CAA77750.1; -; mRNA EMBL AY942181; AAX34409.1; -; mRNA EMBL CH471139; EAW69274.1; -; Genomic_DNA EMBL CH471139; EAW69275.1; -; Genomic_DNA EMBL BC126259; AAI26260.1; -; mRNA EMBL BC136313; AAI36314.1; -; mRNA EMBL M19997; AAA50388.1; -; mRNA CCDS CCDS12117.1; -; . PIR S18294; EFHU2; . RefSeq NP_001952.1; NM_001961.3; . UniGene Hs.515070; -; . PDB 4V6X; EM; 5.00 A; Az=1-858 PDBsum 4V6X; -; . ProteinModelPortal P13639; -; . SMR P13639; -; . BioGrid 108258; 178; . IntAct P13639; 66; . MINT MINT-4999025; -; . STRING 9606.ENSP00000307940; -; . ChEMBL CHEMBL1795108; -; . DrugBank DB02059; Adenosine-5-Diphosphoribose; . DrugBank DB03223; Diphthamide; . DrugBank DB04315; Guanosine-5'-Diphosphate; . iPTMnet P13639; -; . PhosphoSitePlus P13639; -; . SwissPalm P13639; -; . BioMuta EEF2; -; . DMDM 119172; -; . REPRODUCTION-2DPAGE IPI00186290; -; . EPD P13639; -; . MaxQB P13639; -; . PaxDb P13639; -; . PeptideAtlas P13639; -; . PRIDE P13639; -; . DNASU 1938; -; . Ensembl ENST00000309311; ENSP00000307940; ENSG00000167658; . GeneID 1938; -; . KEGG hsa:1938; -; . UCSC uc002lze.4; human; . CTD 1938; -; . DisGeNET 1938; -; . GeneCards EEF2; -; . HGNC HGNC:3214; EEF2; . HPA CAB007795; -; . HPA HPA040534; -; . HPA HPA057351; -; . MalaCards EEF2; -; . MIM 130610; gene; . MIM 609306; phenotype; . neXtProt NX_P13639; -; . OpenTargets ENSG00000167658; -; . Orphanet 101112; Spinocerebellar ataxia type 26; . PharmGKB PA27650; -; . eggNOG KOG0469; Eukaryota; . eggNOG COG0480; LUCA; . GeneTree ENSGT00870000136483; -; . HOGENOM HOG000231589; -; . HOVERGEN HBG001838; -; . InParanoid P13639; -; . KO K03234; -; . OMA FTGHVTR; -; . OrthoDB EOG091G0A2J; -; . PhylomeDB P13639; -; . TreeFam TF300575; -; . Reactome R-HSA-156902; Peptide chain elongation; . Reactome R-HSA-5336415; Uptake and function of diphtheria toxin; . Reactome R-HSA-5358493; Synthesis of diphthamide-EEF2; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-8876725; Protein methylation; . SIGNOR P13639; -; . ChiTaRS EEF2; human; . GeneWiki EEF2; -; . GenomeRNAi 1938; -; . PRO PR:P13639; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000167658; -; . CleanEx HS_EEF2; -; . ExpressionAtlas P13639; baseline and differential; . Genevisible P13639; HS; . GO GO:0016235; C:aggresome; IDA:HPA; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:MGI; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0045121; C:membrane raft; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0042788; C:polysomal ribosome; IEA:Ensembl; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0008097; F:5S rRNA binding; IEA:Ensembl; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0003924; F:GTPase activity; IEA:Ensembl; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0043022; F:ribosome binding; IEA:Ensembl; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:1990416; P:cellular response to brain-derived neurotrophic factor stimulus; IEA:Ensembl; . GO GO:0014009; P:glial cell proliferation; IEA:Ensembl; . GO GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0017183; P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine; TAS:Reactome; . GO GO:2000767; P:positive regulation of cytoplasmic translation; IEA:Ensembl; . GO GO:0045727; P:positive regulation of translation; IMP:UniProtKB; . GO GO:0006479; P:protein methylation; TAS:Reactome; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0032355; P:response to estradiol; IEA:Ensembl; . GO GO:0045471; P:response to ethanol; IEA:Ensembl; . GO GO:0051593; P:response to folic acid; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; . GO GO:0002931; P:response to ischemia; IEA:Ensembl; . GO GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl; . GO GO:0003009; P:skeletal muscle contraction; IEA:Ensembl; . GO GO:0006414; P:translational elongation; TAS:Reactome; . Gene3D 3.30.230.10; -; 1; . Gene3D 3.30.70.240; -; 1; . Gene3D 3.40.50.300; -; 1; . InterPro IPR009022; EFG_III-V; . InterPro IPR000640; EFG_V; . InterPro IPR004161; EFTu-like_2; . InterPro IPR031157; G_TR_CS; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR020568; Ribosomal_S5_D2-typ_fold; . InterPro IPR014721; Ribosomal_S5_D2-typ_fold_subgr; . InterPro IPR005225; Small_GTP-bd_dom; . InterPro IPR000795; TF_GTP-bd_dom; . InterPro IPR009000; Transl_B-barrel; . InterPro IPR005517; Transl_elong_EFG/EF2_IV; . Pfam PF00679; EFG_C; 1; . Pfam PF14492; EFG_II; 1; . Pfam PF03764; EFG_IV; 1; . Pfam PF03144; GTP_EFTU_D2; 1; . PRINTS PR00315; ELONGATNFCT; . SMART SM00838; EFG_C; 1; . SMART SM00889; EFG_IV; 1; . SUPFAM SSF50447; SSF50447; 1; . SUPFAM SSF52540; SSF52540; 1; . SUPFAM SSF54211; SSF54211; 1; . SUPFAM SSF54980; SSF54980; 2; . TIGRFAMs TIGR00231; small_GTP; 1; . PROSITE PS00301; G_TR_1; 1; . PROSITE PS51722; G_TR_2; 1; .

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